RT Book, Section A1 Sarnat, Harvey B. A1 Flores-Sarnat, Laura A2 Carney, Paul R. A2 Geyer, James D. SR Print(0) ID 6654458 T1 Chapter 26. Malformations of the Nervous System in Relation to Ontogenesis T2 Pediatric Practice: Neurology YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-148925-6 LK neurology.mhmedical.com/content.aspx?aid=6654458 RD 2024/03/28 AB Embryonic development of the nervous system is a series of overlapping processes.1 To understand neural development, a traditional view of morphogenesis must be integrated with what we know about molecular genetic programming of the neural tube and fetal brain. Understanding these normal ontogenetic processes is necessary to comprehend neural malformations, which arise as disturbances in one or more of these processes. Malformations of the brain and spinal cord may be caused by genetic mutations or by environmental or acquired influences. Examples of acquired and environmental causes are teratogenic toxins and drugs, fetal ischemia and infarcts, intrauterine trauma from maternal trauma or invasive procedures, cerebral hemorrhages, and infections affecting the fetal brain.