RT Book, Section A1 Czosnowski, Quinn A. A1 George, Jomy M. A2 Lee, Kiwon SR Print(0) ID 1101645820 T1 Antimicrobial Therapies in the ICU T2 The NeuroICU Book YR 2012 FD 2012 PB McGraw-Hill Education PP New York, NY SN 9780071636353 LK neurology.mhmedical.com/content.aspx?aid=1101645820 RD 2024/03/28 AB J.L., a 28-year-old man, was admitted with a severe traumatic brain injury following a motor vehicle crash. He required intubation and mechanical ventilation upon arrival at the hospital. He had no significant past medical or social history. His admission height and weight were 72 inches and 85 kg, respectively.The patient progressed without complication until the morning of hospital day 6. During rounds it is identified that J.L. has an increasing white blood cell count (from 11.4 to 15.1 cells/mm3), was febrile overnight (39°C), and has macroscopically purulent sputum on examination. His morning chest radiograph shows that he has a new right-sided infiltrate. Arterial blood gases (ABGs) on an inspiratory oxygen concentration of 40% are as follows: Pao2 76 mm Hg, Paco2 36 mm Hg, HCO3− 20 mEq/L, and pH 7.31. Blood pressure (BP) is 130/80 mm Hg and heart rate (HR) is 90 bpm. The team suspects late-onset ventilator-associated pneumonia and conducts a bronchoscopic bronchoalveolar lavage (BAL), along with blood and urine cultures. Following the sample collection empiric antibiotics are to be started.