RT Book, Section SR Print(0) ID 1101678157 T1 Modulation of Synaptic Transmission: Second Messengers T2 Principles of Neural Science, Fifth Edition YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-139011-8 LK neurology.mhmedical.com/content.aspx?aid=1101678157 RD 2024/10/10 AB The Cyclic AMP Pathway Is the Best Understood Second Messenger Signaling Cascade Initiated by G Protein-Coupled ReceptorsThe Second-Messenger Pathways Initiated by G Protein-Coupled Receptors Share a Common Molecular LogicA Family of G Proteins Activates Distinct Second-Messenger PathwaysHydrolysis of Phospholipids by Phospholipase C Produces Two Important Second Messengers, IP3 and DiacylglycerolHydrolysis of Phospholipids by Phospholipase A2 Liberates Arachidonic Acid to Produce Other Second MessengersTranscellular Messengers Are Important for Regulating Presynaptic FunctionEndocannabinoids Are Derived from Arachidonic AcidThe Gaseous Second Messengers, Nitric Oxide and Carbon Monoxide, Stimulate Cyclic GMP SynthesisA Family of Receptor Tyrosine Kinases Mediates Some Metabotropic Receptor EffectsThe Physiological Actions of Ionotropic and Metabotropic Receptors DifferSecond-Messenger Cascades Can Increase or Decrease the Opening of Many Types of Ion ChannelsG Proteins Can Modulate Ion Channels DirectlyCyclic AMP-Dependent Protein Phosphorylation Can Close Potassium ChannelsSynaptic Actions Mediated by Phosphorylation Are Terminated by Phosphoprotein PhosphatasesSecond Messengers Can Endow Synaptic Transmission with Long-Lasting ConsequencesAn Overall View