RT Book, Section SR Print(0) ID 1101679711 T1 Pain T2 Principles of Neural Science, Fifth Edition YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-139011-8 LK neurology.mhmedical.com/content.aspx?aid=1101679711 RD 2024/03/29 AB Noxious Insults Activate NociceptorsSignals from Nociceptors Are Conveyed to Neurons in the Dorsal Horn of the Spinal CordHyperalgesia Has Both Peripheral and Central OriginsNociceptive Information Is Transmitted from the Spinal Cord to the ThalamusFive Major Ascending Pathways Convey Nociceptive InformationSeveral Thalamic Nuclei Relay Nociceptive Information to the Cerebral CortexPain Is Controlled by Cortical MechanismsCingulate and Insular Areas Are Active During the Perception of PainPain Perception Is Regulated by a Balance of Activity in Nociceptive and Non-Nociceptive Afferent FibersElectrical Stimulation of the Brain Produces AnalgesiaOpioid Peptides Contribute to Endogenous Pain ControlEndogenous Opioid Peptides and Their Receptors Are Distributed in Pain-Modulatory SystemsMorphine Controls Pain by Activating Opioid ReceptorsTolerance and Addiction to Opioids Are Distinct PhenomenaAn Overall View