RT Book, Section SR Print(0) ID 1101683682 T1 Repairing the Damaged Brain T2 Principles of Neural Science, Fifth Edition YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-139011-8 LK neurology.mhmedical.com/content.aspx?aid=1101683682 RD 2024/10/10 AB Damage to Axons Affects Neurons and Neighboring CellsAxon Degeneration Is an Active ProcessAxotomy Leads to Reactive Responses in Nearby CellsCentral Axons Regenerate Poorly After InjuryTherapeutic Interventions May Promote Regeneration of Injured Central NeuronsEnvironmental Factors Support the Regeneration of Injured AxonsComponents of Myelin Inhibit Neurite OutgrowthInjury-Induced Scarring Hinders Axonal RegenerationAn Intrinsic Growth Program Promotes RegenerationFormation of New Connections by Intact Axons Can Lead to Functional RecoveryNeurons in the Injured Brain Die but New Ones Can Be BornTherapeutic Interventions May Retain or Replace Injured Central NeuronsTransplantation of Neurons or Their Progenitors Can Replace Lost NeuronsStimulation of Neurogenesis in Regions of Injury May Contribute to Restoring FunctionTransplantation of Nonneuronal Cells or Their Progenitors Can Improve Neuronal FunctionRestoration of Function Is the Aim of Regenerative TherapiesAn Overall View