RT Book, Section A1 Amato, Anthony A. A1 Russell, James A. SR Print(0) ID 1115656581 T1 Muscle and Nerve Histopathology T2 Neuromuscular Disorders, 2e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071752503 LK neurology.mhmedical.com/content.aspx?aid=1115656581 RD 2024/10/12 AB Muscle and nerve biopsies can be extremely useful in the evaluation of patients with myopathies and neuropathies. That said, not everyone suspected of having a muscle or nerve disorder needs a biopsy. In this chapter, we discuss the indications and limitations for muscle and nerve biopsies, how specific muscle or nerves are selected for biopsy, and various aspects of specimen handling. Further, we review the routine stains that are performed on muscle and nerve tissue, other stains or studies that can be performed on the tissue, and when to order them. We also mention the role of skin biopsy to assess epidermal nerve fibers in the evaluation of patients with peripheral neuropathy. This chapter is not designed to make the reader a neuropathologist. However, clinicians who take care of patients with neuromuscular disease and order biopsies should have at least a working knowledge of muscle and nerve histopathology.