RT Book, Section
A1 Amato, Anthony A.
A1 Russell, James A.
SR Print(0)
ID 1115661187
T1 Muscular Dystrophies
T2 Neuromuscular Disorders, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071752503
LK neurology.mhmedical.com/content.aspx?aid=1115661187
RD 2024/04/25
AB Muscular  dystrophies  are  hereditary,  progressive  muscle  diseases  in  which  there  is  necrosis  of  muscle  tissue  and  replacement  by  connective  and  fatty  tissues,  which  helps  to  distinguish  them  from  other  hereditary  myopathies.  Before  discussing  specific  types  of  muscular  dystrophies,  it  is  important  to  have  an  understanding  of  the  relevant  muscle  proteins  that  are  affected  in  the  various  dystrophies.  The  different  forms  of  muscular  dystrophies  result  from  mutations  affecting  proteins  localizable  to  the  sarcolemma,  myonuclei,  basement  membrane  and  extracellular  matrix  surrounding  muscle  fibers,  sarcomere  and  nonstructural  enzymatic  proteins.1,2