RT Book, Section
A1 Amato, Anthony A.
A1 Russell, James A.
SR Print(0)
ID 1115663110
T1 Toxic Myopathies
T2 Neuromuscular Disorders, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071752503
LK neurology.mhmedical.com/content.aspx?aid=1115663110
RD 2024/04/23
AB Many  drugs  can  cause  a  myopathy.1–10  The  pathophysiological  mechanisms  are  diverse  and,  in  many  instances,  unclear.  Medications  can  have  either  a  direct  or  an  indirect  adverse  effect  on  muscle.  The  direct  effect  can  be  focal,  as  might  occur  secondary  to  a  drug  being  injected  into  tissue,  or  more  commonly  generalized.  Indirect  toxic  effects  may  result  from  the  agent  creating  an  electrolyte  imbalance  or  inducing  an  immunological  reaction.  Muscle  fibers  may  undergo  necrosis  as  a  result  of  the  drug  directly  disrupting  the  sarcolemma,  nuclear  or  mitochondria  function,  or  that  of  other  organelles.  In  this  chapter,  we  classify  the  toxic  myopathies  according  to  their  presumed  pathogenic  mechanisms  (Table  35-1).