Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. Maternal preeclampsia linked with increased risk of neurodevelopmental disorders. 2 Minute Medicine, 16 April 2020. McGraw-Hill, 2020. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=547785§ionid=245113697APA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. (2020). Maternal preeclampsia linked with increased risk of neurodevelopmental disorders. (2020). 2 minute medicine. McGraw-Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=547785§ionid=245113697.MLA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. "Maternal preeclampsia linked with increased risk of neurodevelopmental disorders." 2 Minute Medicine McGraw-Hill, 2020, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=547785§ionid=245113697. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Maternal preeclampsia linked with increased risk of neurodevelopmental disorders by Alex Chan, Ravi Shah Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Maternal preeclampsia at term was associated with an increased risk of neurodevelopmental disorders in offspring. +Evidence Rating: 1 (Excellent) +While the risks associated with preeclampsia are well established for the mother, the associated outcomes and risks for the offspring are relatively less well characterized. Preeclampsia has previously been linked to cerebral palsy, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) in offspring, but few studies have distinguished between term and preterm preeclampsia. In this prospective cohort study, researchers investigated the association between maternal preeclampsia in term births with a variety of neurodevelopmental disorders in a cohort of 980,560 Norwegian offspring born at term between 1991 and 2009. Among the children included in the study, 28,068 (2.9%) were exposed to preeclampsia in utero, with 273 cases progressing to eclampsia. During a mean follow up period of 14.0 (SD 5.6) years, offspring exposed to preeclampsia prior to birth were found to have a higher risk of ADHD (adjusted OR, 1.18; 95% CI, 1.05-1.330, ASD (adjusted OR, 1.29; 95% CI, 1.08-1.54), epilepsy (adjusted OR, 1.50; 95% CI, 1.16-1.93), and intellectual disability (adjusted OR, 1.50; 95% CI, 1.13-1.97), with a trend toward a higher risk of cerebral palsy (adjusted OR, 1.30; 95% CI, 0.94-1.80). Analyses were made with adjustment for sex, year of birth, maternal age, parity, and other potentially confounding factors. Although these outcomes were still rare among the cohort, this study represents the most comprehensive investigation evaluating the association between maternal preeclampsia and neurodevelopment to date, and provides evidence that preeclampsia may have broad effects on neurodevelopment independent of preterm birth. Further investigation of this association may provide a basis for screening or intervention in the future for the benefit of offspring born under these conditions. +Click to read the study in JAMA Psychiatry +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.