Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. Multiple sclerosis patient at higher risk for cerebrovascular and cardiovascular disease. 2 Minute Medicine, 1 June 2020. McGraw-Hill, 2020. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550494§ionid=247750714APA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. (2020). Multiple sclerosis patient at higher risk for cerebrovascular and cardiovascular disease. (2020). 2 minute medicine. McGraw-Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550494§ionid=247750714.MLA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. "Multiple sclerosis patient at higher risk for cerebrovascular and cardiovascular disease." 2 Minute Medicine McGraw-Hill, 2020, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550494§ionid=247750714. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Multiple sclerosis patient at higher risk for cerebrovascular and cardiovascular disease by Jack Lennon, Ravi Shah, MD MBA Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Compared to healthy matched controls, individuals with multiple sclerosis demonstrated significantly increased risk of cerebrovascular disease, acute coronary syndrome, cardiovascular disease-related mortality, and all-cause mortality. +Evidence Rating Level: 2 (Good) +Multiple sclerosis (MS) is an autoimmune disease characterized by the demyelination of nerve fibers in the central nervous system, resulting in severe pain, decreased mobility, fatigue, and vision loss. MS is also associated with cardiovascular disease and mortality. However, population-based studies on this relationship are limited. This population-based, retrospective matched cohort study among participants in England investigated the risk of major cardiovascular events and mortality in MS and healthy matched controls. A total of 12,251 participants with MS (M [SD] age = 44.9 [13.3] years, 66.9% female) and without MS (mean [SD] age = 44.9 [13.3] years, 69.8% female) were included in analyses. MS participants demonstrated increased risk of cerebrovascular disease (HR 1.59, 95% CI 1.32 to 1.92), acute coronary syndrome (HR 1.28, 95% CI 1.09 to 1.51), any major vascular disease (HR 1.32, 95% CI 1.15 to 1.52), all-cause mortality (HR 3.46, 95% CI 3.28 to 3.65), and cardiovascular disease-related mortality (HR 1.47, 95% CI 1.27 to 1.71). Mortality risk and occurrence of major vascular events were higher among women. Regarding treatment, lipid-reducing medications such as statins were associated with lower rates of mortality among individuals with MS. Overall, this study illustrates the risk factor MS poses for affected individuals and points toward future directions of research on MS. +Click to read the study in JAMA Neurology +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.