Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Chawla A, Chan A. Chawla A, & Chan A Chawla, Aikansha, and Alex Chan. Maternal anemia in pregnancy may be associated with subsequent brain structure changes in offspring. 2 Minute Medicine, 7 December 2022. McGraw Hill, 2022. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=605866§ionid=273738975APA Citation Chawla A, Chan A. Chawla A, & Chan A Chawla, Aikansha, and Alex Chan. (2022). Maternal anemia in pregnancy may be associated with subsequent brain structure changes in offspring. (2022). 2 minute medicine. McGraw Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=605866§ionid=273738975.MLA Citation Chawla A, Chan A. Chawla A, & Chan A Chawla, Aikansha, and Alex Chan. "Maternal anemia in pregnancy may be associated with subsequent brain structure changes in offspring." 2 Minute Medicine McGraw Hill, 2022, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=605866§ionid=273738975. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Maternal anemia in pregnancy may be associated with subsequent brain structure changes in offspring by Aikansha Chawla, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Anemia during pregnancy associated with altered brain structure in children including smaller volumes of bilateral caudate, putamen and corpus callosum +Evidence Rating Level: 2 (Good) +It is estimated that 38% of pregnant women worldwide are anemic. Anemia is known to be a risk factor for poor maternal and infant health outcomes, however limited studies have been done to determine the association of maternal anemia with child brain structure. This cohort study sought to further investigate this association by examining the subsequent brain structure changes of 147 mother child pairs. Mothers had hemoglobin levels measured during pregnancy and these levels were adjusted for trimester of pregnancy. Children had brain magnetic imaging done at age 2-3 years, hemoglobin was only measured in children if they had hospital visits between birth and MRI. Of the 147 mothers, 31% were found to have anemia in pregnancy. After adjusting for covariates, maternal anemia was not found to be associated with child global brain volumes but significant associations between individual structures were identified including: smaller volumes of bilateral caudate, putamen and corpus callosum (−5.30% [95% CI, −7.01 to −3.59, −4.33% [95% CI, −5.74 to −2.92], −7.75% [95% CI, −11.24 to −4.26] respectively). Not all of the children in the study had hemoglobin measurements taken, however within those who did child anemia was not found to be associated with brain volume changes. Limitations to this study include a high-risk group as many participants had maternal HIV and alcohol use, as well as a small sample size for child anemia. Additionally, this study did not include any longitudinal findings, limiting the ability of the study to further extrapolate subsequent neurodevelopmental outcomes. Overall, this study shows that maternal anemia has an association with brain development in children, and optimizing interventions to manage maternal anemia may have a positive impact on brain development. +Click to read the study in JAMA Network Open +©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.