Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. Tenecteplase and alteplase demonstrate similar efficacy for acute ischemic stroke. 2 Minute Medicine, 24 March 2025. McGraw Hill, 2025. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=653388§ionid=293483365APA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. (2025). Tenecteplase and alteplase demonstrate similar efficacy for acute ischemic stroke. [publicationyear2] 2 minute medicine. McGraw Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=653388§ionid=293483365.MLA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. "Tenecteplase and alteplase demonstrate similar efficacy for acute ischemic stroke." 2 Minute Medicine McGraw Hill, 2025, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=653388§ionid=293483365. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Tenecteplase and alteplase demonstrate similar efficacy for acute ischemic stroke by Simon Pan, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. The usage of tenecteplase in patients with acute ischemic stroke was associated with similar effectiveness and safety compared with the use of alteplase. +Evidence Rating Level: 2 (Good) +Current agents used in the thrombolytic management of acute ischemic stroke include tenecteplase and alteplase. Recent studies have shown that tenecteplase has at least similar effectiveness as alteplase in the management of acute ischemic stroke, yet there is a lack of real-world data comparing the two agents in routine clinical practice. This nationwide prospective cohort study therefore sought to investigate the safety and efficacy of tenecteplase compared to alteplase in the management of acute ischemic stroke. 79,550 patients (mean [SD] age, 69.6 [14.7] years; 52.4% male) with a final discharge diagnosis of acute ischemic stroke from the United States-based GWTG-Stroke registry were included for analysis. The primary endpoint for the study was functional independence on discharge as measured by the modified Rankin Scale (mRS) with safety endpoints including symptomatic intracranial hemorrhage (sICH) within 36 hours and in-hospital mortality. There was no difference in functional independence between the use of tenecteplase and alteplase (AOR, 1.00; 95% CI, 0.93-1.07). For safety outcomes, there was no difference in the rates of sICH (AOR, 0.96; 95% CI, 0.83-1.11) and in-hospital mortality (AOR, 0.95; 95% CI, 0.84-1.06) between those receiving tenecteplase and alteplase. Overall, this study found that the use of tenecteplase in patients with acute ischemic stroke was associated with similar effectiveness and safety outcomes as alteplase. +Click to read the study in JAMA Network Open +©2025 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.